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The guanylate cyclase converts a chemical substance called GTP into another chemical known as cGMP. CGMP causes muscles in the walls of the arteries to unbend. Meanwhile, PDE is decomposing the cGMP and turn it second into GTP. Thither is a pedal -- guanylate cyclase turns GTP into cGMP, and PDE turns cGMP into GTP. Starting in the mid-1980s, it became vernacular for manpower with erectile disfunction to shoot smooth-muscle-reposeful drugs as a discussion for the problem.